Mohamed Abouzid
@pums.ump.edu.pl
Department of Physical Pharmacy and Pharmacokinetics
Poznan University of Medical Sciences
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Mohamed Riad Abouzid, Ibrahim Kamel, Anu Radha Twayana, Suraj Shrestha, Amr Saleh, Shorouk Elshafei, Jack Jenkins, Ahmad Hallak, and James Jenkins
Elsevier BV
Mohamed Abouzid, Łukasz Kruszyna, Julia Kerner, Leonid Kagan, Aniceta Mikulska-Sauermann, Dorota Filipowicz, Matylda Resztak, Franciszek Krzysztof Główka, and Marta Karaźniewicz-Łada
Portland Press Ltd.
Roughly 90% of the Polish population experiences vitamin D deficiency. The 3-epi-25(OH)D2 and 3-epi-25(OH)D3 are stereoisomers of 25(OH)D2 and 25(OH)D3, and they can inadvertently be included in measurements of 25(OH)D levels, potentially leading to its overestimating. We aimed to measure 25(OH)D2 and 25(OH)D3, their epimers 3-epi-25(OH)D2 and 3-epi-25(OH)D3, and biologically active 1,25(OH)2D3 in patients with cardiovascular disease and healthy volunteers. We enrolled 27 adult patients with cardiovascular disease (64 ±15 years) and 35 healthy volunteers (36.37±12.29 years). We used a validated UPLC-MS/MS method to measure 25(OH)D2/3 concentrations and their epimers. Plasma concentrations of 1α,25(OH)2D3 were determined by sensitive and quantitative enzyme immunoassay following intra- and inter-day validation. Vitamin D insufficiency was observed in approximately 52% of the patients and 37% of healthy volunteers. Comparable levels of 25(OH)D3 and 25(OH)D2 were seen in both groups. The observed levels of the epimeric form 3-epi-25(OH)D3 appeared about 1.7 times higher in healthy volunteers, accounting for 9% misclassified according to vitamin D status. Also, patients had lower concentrations of 1,25(OH)2D3, and their 3-epi-25(OH)D2 levels were below the detection limit (2 ng/mL). In all studied subjects, 25(OH)D3 was negatively correlated with % 3-epi-25(OH)D3 (R=-0.758; p<0.001), and 3-epi-25(OH)D2 was negatively correlated with % 3-epi-25(OH)D2 (R = -0.842; p=0.002). While the mechanism of how vitamin D epimeric forms influence diseases remains unclear, we recommend maintaining 25(OH)D3 levels above 20 ng/mL.
Mohamed S. Hemeda, Heba Youssef Sayed, Amany A. Mostafa, Almaza Ali Salem, Ibrahim Arafa Reyad Arafa, Hesham Hafez Abdelkhalek Mosa, Mohamed Hafez Mohamed Younes, Samar S. Ahmed, Yasser M. Saqr, Amir Bastawisy,et al.
Elsevier BV
Mohammad Tanashat, Mohamed Abuelazm, Mohamed Abouzid, Yazan A. Al-Ajlouni, Alaa Ramadan, Sumaya Alsalah, Abdulrahman Sharaf, Dina Ayman, Hesham Elharti, Sara Zhana,et al.
Elsevier BV
Abdallah Abbas, Mohamed Abouzid, Haneen Sabet, Ahmed Mansour, Abdelfattah Arafa, Ahmed Elshahat, Ahmed Mostafa Amin, Mahmoud Tarek Hefnawy, Mohamed El-Moslemani, Amna Hussein,et al.
Springer Science and Business Media LLC
Enas A. Amaireh, Leen H. Asfour, Suha Shraim, Ruba Altheeb, Rana M. Haddad, Ghaidaa S. Khlaifat, Ghadeer M. Alsheikh, Ibrahim Serag, Mohamed Abouzid, and Mohammad Ghassab Deameh
Springer Science and Business Media LLC
Obieda Altobaishat, Omar Abdullah Bataineh, Ahmed A. Ibrahim, Ahmad K. Al-zoubi, Ubaid Khan, Mahmoud Shaaban Abdelgalil, Mohamed Abouzid, Hazem Rezq, and Mohamed Abuelazm
Elsevier BV
OBJECTIVE
Acute type A aortic dissection (ATAAD) is a cardiovascular emergency with high mortality and morbidity. We compared the effects on outcomes of single arterial cannulation (SAC) via axillary, femoral, or ascending aorta with double arterial cannulation (DAC) via axillary and femoral artery during ATAAD repair.
METHODS
We conducted a systematic review and meta-analysis of observational studies from PubMed, Web of Science, Scopus, EMBASE, and Cochrane searches through April 30, 2024. Dichotomous data were pooled using risk ratio (RR), and continuous data were pooled using mean difference (MD), both with a 95% confidence interval (CI), using R version 4.3. The protocol is registered on PROSPERO (CRD42024535644).
RESULTS
Our analysis included 7 studies encompassing 3,534 patients. DAC was associated with a significantly longer intensive care unit stay than SAC (MD 0.45 days, 95% CI 0.10, 0.79, p = 0.01). However, there was no significant difference between DAC and SAC in the length of hospital stay (MD 1.39 days, 95% CI -2.70, 5.47, p = 0.51). Also, there was no significant difference between the two approaches in the incidence of stroke (RR 1.12, 95% CI 0.77, 1.64, p = 0.55), paraplegia (RR 0.59, 95% CI 0.32, 1.07, p = 0.08), or acute kidney injury (RR 0.83, 95% CI 0.55, 1.24, p = 1.24).
CONCLUSION
Our meta-analysis shows that during ATAAD repair, DAC was associated with slightly longer intensive care stay, which was of doubtful clinical significance. However, both approaches were comparable for hospital stay, the incidence of stroke, paraplegia, or acute kidney injury.
IMPLICATIONS FOR CLINICAL PRACTICE
Despite comparable overall outcomes, we observed that DAC was associated with higher risks of requiring continuous renal replacement therapy or dialysis, and reintubation. This emphasizes the need to carefully consider cannulation strategies based on patient factors to balance potential benefits and risks.
Mohamad Riad Abouzid, Ankit Vyas, Ibrahim Kamel, Junaid Anwar, Shorouk Elshafei, Venkat Subramaniam, William Bennett, Carl J. Lavie, Chima Nwaukwa, Christopher J. White,et al.
Elsevier BV
Ahmed E. Ali, Mohamed K. Awad, Karim Ali, Mohamed Riad Abouzid, Marwan H. Ahmed, and Muhammad S. Mazroua
Springer Science and Business Media LLC
Maanya Rajasree Katta, Mohamed Riad Abdelgawad Abouzid, Maha Hameed, Jasneet Kaur, and Suryakumar Balasubramanian
Ovid Technologies (Wolters Kluwer Health)
Cardiac pacing refers to the implantation tool serving as a treatment modality for various indications, the most common of which is symptomatic bradyarrhythmia. Left bundle branch pacing has been noted in the literature to be safer than biventricular pacing or His-bundle pacing in patients with left bundle branch block (LBBB) and heart failure, thereby becoming the focus of further research on cardiac pacing. A review of the literature was conducted using a combination of keywords, including “Left Bundle Branch Block,” “Procedural techniques,” “Left Bundle Capture,” and “Complications.” The following factors have been investigated as key criteria for direct capture: paced QRS morphology, peak left ventricular activation time, left bundle potential, nonselective and selective left bundle capture, and programmed deep septal stimulation protocol. In addition, complications of LBBP, inclusive of septal perforation, thromboembolism, right bundle branch injury, septal artery injury, lead dislodgement, lead fracture, and lead extraction, have also been elaborated on. Despite clinical implications based on clinical research comparing the use of LBBP with other forms such as right ventricular apex pacing, His-bundle pacing, biventricular pacing, and left ventricular septal pacing, a paucity in the literature on long-term effects and efficacy has been noted. LBBP can thus be considered to have a promising future in patients requiring cardiac pacing, assuming that additional research on clinical outcomes and the limitation of significant complications such as thromboembolism can be established.
Mohammad Al-Jafari, Marah Ahmad Aldarawsheh, Mohamed Abouzid, Ibrahim Serag, Mariam Akram Nofal, Ammar Ra’ed Altiti, Saja Zuaiter, Aya Sabri Al-Zurgan, Basil Aldiabat, Julie Feras Owaidat,et al.
Springer Science and Business Media LLC
Mohamed Hendawy, Mohamed Abouzid, Aliaa Gamal, Aseel Ghanayem, Muna Amer, Mohammad Tanashat, Nael Kamel Eltewacy, Mohamed Mustafa Mohamed, Eman Ayman Nada, and Ismail A. Ibrahim
Springer Science and Business Media LLC
Abstract Background Psychological distress has significantly impacted students in Egypt and Jordan. These countries have faced many challenges, including the COVID-19 pandemic, the fallout from the conflict in Syria, and the war in Ukraine. These crises have had far-reaching consequences, affecting the economy, food security, and energy supplies, particularly with the increased number of refugees in these countries. Amid these existing complexities, the ongoing war in Gaza further exacerbates the situation, compounding mental health challenges. Therefore, this study aimed to analyze how the war in Gaza impacted the mental health of students in Egypt and Jordan. Methods We conducted a cross-sectional study involving students from Egypt and Jordan between December 2023 and January 2024. The questionnaire incorporated the Brief Symptom Inventory 18 (BSI-18) to assess the overall general distress score, as well as the domains of anxiety, somatization, and depression. Results A total of 1509 Jordanian and Egyptian students were included in the study, of which 66% were female. Approximately 18% of the students had an elevation (≥ 50) in their BSI-18 total score. Females scored significantly higher in general distress [30 (18–44.25) vs. 24 (11–41), p < 0.001], and all three dimensions. The univariate predictors for elevated general distress (≥ 50) were being Egyptian (OR 1.49, 95% CI 1.08 to 2.08, p = 0.014), watching social media multiple times a day (OR 3.04, 95% CI 1.97 to 4.69, p < 0.001), and having a Palestinian connection (friend, neighbor, colleague, or relative) (OR 1.63, 95% CI 1.23 to 2.16, p < 0.001). These three predictors were retained in the backward stepwise multivariate regression analysis model. The univariate predictors for moderate and marked general distress (≥ 57) were watching social media multiple times a day (OR 3.26, 95% CI 1.78 to 5.99, p < 0.001) and having a Palestinian connection (OR 1.49, 95% CI 1.05 to 2.14, p = 0.026). Only the former was retained in the backward stepwise multivariate regression analysis. Conclusion General distress has increased among students in Egypt and Jordan throughout the War in Gaza. Mental, psychological, and social support activities are necessary for these students, particularly those watching social media multiple times daily. The development of coping skills to manage the additional stressors of war and socioeconomic status necessitates further research within this group of students.
Ahmed M. Elgarahy, M. G. Eloffy, Ayman N. Saber, Mohamed Abouzid, Emanne Rashad, Mohamed A. Ghorab, Dina M. El-Sherif, and Khalid Z. Elwakeel
Springer Science and Business Media LLC
Khalid Sarhan, Reem Reda Elmahdi, Rashad G. Mohamed, Ibrahim Serag, and Mohamed Abouzid
Springer Science and Business Media LLC
AbstractSuturing techniques for wound closure in spine surgeries play a critical role in patient outcomes, including wound healing, reintervention, and risk of complications. Barbed sutures, characterized by their self-anchoring properties, have emerged as a potential alternative to conventional sutures in various surgical disciplines. While previous studies have underscored their efficacy and safety in spine surgeries, no meta-analysis has been conducted. Therefore, we are undertaking this study. Following the PRISMA guidelines, we conducted a literature search on electronic databases to obtain the relevant studies until May 5, 2024. Our primary outcomes were operative time, wound closure time, and postoperative wound complications like seroma or hematoma formation and wound infection. The secondary outcomes were the length of hospital stay, reintervention rates, and costs. Data was pooled using a random effects model. We included seven eligible studies with a total of 8645 patients. Our meta-analysis showed that barbed sutures had shorter operative time and wound closure time compared to conventional sutures (MD -20.13 min, 95% CI [-28.47, -11.78], P < 0.001) and (MD -16.36 min, 95% CI [-20.9, -11.82], P < 0.001), respectively. Both suturing techniques showed comparable results in terms of overall postoperative wound complications (RR 0.83, 95% CI [0.60, 1.14], P = 0.25), postoperative infections (RR 0.59, 95% CI [0.33, 1.06], P = 0.08), length of hospital stay (MD -0.26 day, 95% CI [-0.75, 0.22], P = 0.28), rates of reintervention between the two groups (RR 0.99, 95% CI [0.48, 2.05], P = 0.98). Barbed sutures in spine surgeries are associated with significantly shortened wound closure and operative times. However, high-quality RCT’s with long-term follow-up and cost-effectiveness assessment are required to support the evidence.
Ahmed A. Abo Elnaga, Mohamed A. Alsaied, Abdelrahman M. Elettreby, Alaa Ramadan, Mohamed Abouzid, Raghda Shetta, and Yazan A. Al-Ajlouni
Springer Science and Business Media LLC
Abdelaziz A. Awad, Menna M. Aboelkhier, Rashad G. Mohamed, Ahmed W. Abbas, Ahmed W. Hageen, Yousef R. Alnomani, and Mohamed Abouzid
Springer Science and Business Media LLC
Abstract Purpose of Review Ontamalimab is an anti-MAdCAM-1 monoclonal antibody. It directly restricts the binding of α4β7 + lymphocytes and does not affect the homing of lymphocytes in the central nervous system. Thus, it diminishes adverse effects while blocking their migration into the gut. Several clinical trials have validated the efficacy and safety of ontamalimab for Crohn's disease and ulcerative colitis. However, to date, there is no meta-analysis on the topic. Hence, we are conducting this meta-analysis. Using R version R.3.3, we reported outcomes as risk ratios (RRs) or mean difference (MD) and confidence intervals (CIs). A P-value ≤ 0.05 is considered as statistically significant. Recent Findings The meta-analysis included a total of three studies with 1384 patients. In patients with ulcerative colitis, compared to placebo, ontamalimab had significantly improved clinical remission (RR = 2.17, 95% CI [1.42 to 3.32], P < 0.01), clinical response (RR = 1.79, 95% CI [1.35 to 2.38], P < 0.01), endoscopic response (RR = 2.27, 95% CI [1.55 to 3.31], P < 0.01) and mucosal healing (RR = 2.39, 95% CI [1.63 to 3.50], P < 0.01). No significant differences favoring ontamalimab or the placebo were found regarding safety outcomes. In patients with Crohn's disease, ontamalimab showed superiority over placebo in endoscopic response (RR = 2.00, 95% CI [1.08 to 3.70], P = 0.03). However, ontamalimab was associated with a higher incidence of serious adverse events, and study discontinuations were due to adverse events. Summary Ontamalimab has shown promising results, particularly in patients with moderate to severe ulcerative colitis, as evidenced by better clinical response and remission. However, questions remain about its long-term effectiveness and safety; hence, extended follow-up and more extensive studies are necessary.
Yazan A. Al-Ajlouni, Mohamed Abouzid, Mohammad Tanashat, Ahmed Ahmed Basheer, Omar Al Ta’ani, Naciye Bilgin-Badur, and Mohammad Islam
Springer Science and Business Media LLC
Ibrahim Serag and Mohamed Abouzid
Springer Science and Business Media LLC
Alaa Ramadan, Heba Aboeldahab, Mohamed Nabih Bashir, Mohamed Mohamed Belal, Ahmed Wageeh, Ahmed Atia, Mohamed Elbanna, Tala Jouma Alhejazi, Mohamed Abouzid, Hady Atef,et al.
Springer Science and Business Media LLC
Abstract Background Cardiovascular disease (CVD) represents a significant health challenge in Egypt, yet there exists limited understanding regarding the knowledge, attitudes, and physical activity levels associated with CVD. These factors play a pivotal role in developing effective prevention and management strategies. Hence, this cross-sectional study aimed to evaluate Egyptian adults’ knowledge, attitudes, and physical activity (KAP) levels. Methods Data were collected using a previously validated questionnaire encompassing demographic characteristics, CVD knowledge (including risk factors and symptoms), attitudes toward CVD, and self-reported physical activity levels. The survey was distributed among social media channels, and trained researchers administered the questionnaire via face-to-face interviews with adult patients with and without CVD admitted to Cairo University Hospital clinics. Results The study involved 591 participants, of whom 21.7% had CVD. Overall, participants exhibited poor knowledge regarding CVD, with a mean score of 21 ± 7 out of 40, equivalent to 52.5%. Attitudes toward CVD were moderate, with a mean score of 66.38 ± 8.7 out of 85, approximately 78%. Physical activity levels per week were also moderate, averaging 1188 MET-min with a range of 1121–18,761. Subgroup analysis revealed that individuals with CVD had lower average knowledge, attitude, and physical activity levels than those without CVD. Working in the healthcare field was a predictor of higher knowledge score (standard error (SE) 5.89, 95% confidence interval (CI) 4.61 to 7.17, P < 0.001), while those with CVD and smokers were predictors of lower attitude score (SE -4.08, 95% CI -6.43 to -1.73, P < 0.001) and (SE -2.54, 95% CI -4.69 to -0.40, P = 0.02), respectively. Conclusion The study findings highlight a significant disparity in knowledge, attitudes, and physical activity levels related to CVD in Egypt. Targeted interventions aimed at improving awareness, fostering positive attitudes, and promoting physical activity among individuals at risk for CVD are crucial for effective prevention and management.
Mariam Ahmed Abdelhady, Ahmed Aljabali, Mohammad Al-Jafari, Ibrahim Serag, Amr Elrosasy, Ahmed Atia, Aya Ehab, Shrouk F. Mohammed, Ibraheem M. Alkhawaldeh, and Mohamed Abouzid
Springer Science and Business Media LLC
Abstract Background Surgery is the primary treatment for chronic subdural hematoma, and anesthesia significantly impacts the surgery's outcomes. A previous systematic review compared general anesthesia to local anesthesia in 319 patients. Our study builds upon this research, analyzing 4,367 cases to provide updated and rigorous evidence. Methods We systematically searched five electronic databases: PubMed, Cochrane Library, Scopus, Ovid Medline, and Web of Science, to identify eligible comparative studies. All studies published until September 2023 were included in our analysis. We compared six primary outcomes between the two groups using Review Manager Software. Results Eighteen studies involving a total of 4,367 participants were included in the meta-analysis. The analysis revealed no significant difference between the two techniques in terms of 'recurrence rate' (OR = 0.95, 95% CI [0.78 to 1.15], P = 0.59), 'mortality rate' (OR = 1.02, 95% CI [0.55 to 1.88], P = 0.96), and 'reoperation rate' (OR = 0.95, 95% CI [0.5 to 1.79], P = 0.87). Local anesthesia demonstrated superiority with a lower 'complications rate' than general anesthesia, as the latter had almost 2.4 times higher odds of experiencing complications (OR = 2.4, 95% CI [1.81 to 3.17], P < 0.00001). Additionally, local anesthesia was associated with a shorter 'length of hospital stay' (SMD = 1.19, 95% CI [1.06 to 1.32], P < 0.00001) and a reduced 'duration of surgery' (SMD = 0.94, 95% CI [0.67 to 1.2], P < 0.00001). Conclusion Surgery for chronic subdural hematoma under local anesthesia results in fewer complications, a shorter length of hospital stay, and a shorter duration of the operation.
Ahmed Aljabali, Ibrahim Serag, Sherein Diab, Abdulhameed Zeyad Alhadeethi, Mariam Abdelhady, Ibraheem M. Alkhawaldeh, and Mohamed Abouzid
Springer Science and Business Media LLC
Ibrahim Serag, Mohamed Abouzid, Ahmed Elmoghazy, Khalid Sarhan, Saad Ashraf Alsaad, and Rashad G. Mohamed
Springer Science and Business Media LLC
Ibrahim A. Bakry, Mohamed Abouzid, Wei Wei, Jun Jin, Xingguo Wang, Ning Li, Ahmed Fathy Ghazal, Abdelaziz Elbarbary, Amal Gohary, and Ahmed H. Mousa
Elsevier BV
Mohammad Tanashat, Almothana Manasrah, and Mohamed Abouzid
Springer Science and Business Media LLC
Valery L Feigin, Melsew Dagne Abate, Yohannes Habtegiorgis Abate, Samar Abd ElHafeez, Foad Abd-Allah, Ahmed Abdelalim, Atef Abdelkader, Michael Abdelmasseh, Sherief Abd-Elsalam, Parsa Abdi,et al.
Elsevier BV