Mehmet Maruf BALOS
@harran.edu.tr
Şanlıurfa Provincial Directorate of National Education, Fatma Zehra Girls Anatolian Imam Hatip High School
EDUCATION
Blacksea Technical University, Fatih education faculty, biology teacher
Harran University
RESEARCH INTERESTS
Plant systematics, Plant Morphology, Plant Anatomy, phytochemistry
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Mehmet Maruf Balos, Cahit Çeçen, Mehtap Tekşen, Hasan Yıldırım, and Veysel Sonay
Wiley
Fritillaria yalcinii (Liliaceae) is described as a new species from Diyarbakır Province, southeastern Turkey. It is superficially similar to F. carica, F. forbesii, F. minima, F. minuta, F. mughlae and F. sibthorpiana, but differs in several morphological characters, such as leaves, perigon, nectary, filament, stigma and anther. Diagnostic characteristics, a comprehensive description, photographs, geographical distribution, conservation assessment, observations and a distribution map are provided.
Ismail Koyuncu, Ebru Temiz, Fatma Seker, M. Maruf Balos, Feridun Akkafa, Ozgür Yuksekdag, M. Abdullah Yılmaz, and Gokhan Zengin
Wiley
AbstractThis research investigates the potential use of Jurinea mesopotamica Hand.‐Mazz. (Asteraceae) in cancer treatment. In this study, a plant extract was prepared using all parts of J. mesopotamica, and its effect on the proliferation of cancer and normal cells was tested using the MTT method. It was found to have a selective cytotoxic effect on prostate cancer cells, with the lowest IC50 (half‐maximal inhibitory concentration) of 10μg/mL found in the butanol extract (JMBE). The extract suppressed the proliferation of prostate cancer cells (67 %), disrupted organelle integrity (49 %), increased reactive oxidative stress (66 %), and triggered cell death (51 %). In addition, apoptotic gene expressions and protein levels increased, and the profile of amino acids related to energy metabolism was elevated. Based on LC–MS/MS results, the plant contained higher levels of flavonoids, including isoquercitrin, cosmosiin, astragalin, nicotiflorin, luteolin, and apigenin. These results suggest that J. mesopotamica has a selective effect on prostate cancer due to its high flavonoid content and might be a promising natural alternative for cancer treatment.
Stefano Dall'Acqua, Sakina Yagi, Stefania Sut, Abdullahi Ibrahim Uba, Sathish Kumar M. Ponniya, Ismail Koyuncu, Kenan Toprak, Mehmet Maruf Balos, Alevcan Kaplan, Uğur Çakılcıoğlu,et al.
Wiley
AbstractTanacetum nitens ( Boiss. & Noë) Grierson is an aromatic perennial herb used in Turkish traditional medicine to treat headache, fever, and skin diseases. This study aimed to investigate the chemical composition, antioxidant, enzyme inhibition, and cytotoxic properties of T. nitens aerial parts. Organic solvent extracts were prepared by sequential maceration in hexane, dichloromethane, ethyl acetate, and methanol while aqueous extracts were obtained by maceration or infusion. Nuclear magnetic resonance (NMR) and LC‐DAD‐MS analysis allowed the identification and quantification of different phytoconstituents including parthenolide, tanacetol B, tatridin B, quinic acid derivatives, β‐sitosterol, and glycoside derivatives of quercetin and luteolin. The type and amount of these phytochemicals recovered by each solvent were variable and significant enough to impact the biological activities of the plant. Methanolic and aqueous extracts displayed the highest scavenging and ions‐reducing properties while the dichloromethane and ethyl acetate extracts exerted the best total antioxidant activity and metal chelating power. Results of enzyme inhibition activity showed that the hexane, ethyl acetate, and dichloromethane extracts had comparable anti‐acetylcholinesterase activity and the latter extract revealed the highest anti‐butyrylcholinesterase activity. The best α‐amylase and α‐glucosidase inhibition activities were obtained from the hexane extract. The dichloromethane and ethyl acetate extracts exhibited the highest cytotoxic effect against the prostate carcinoma DU‐145 cells. In conclusion, these findings indicated that T. nitens can be a promising source of biomolecules with potential therapeutic applications.
İsmail Eker and Mehmet Maruf Balos
Finnish Zoological and Botanical Publishing Board
Fritillaria ecerii Balos & Eker sp. nova (Liliaceae) is described from the province of Mardin, SE Anatolia, Turkey. It is morphologically similar to F. melananthera in having a striped perigone, to F. caucasica and F. baskilensis in having a long style, and to F. assyriaca in having the same number of leaves. However, it clearly differs from F. melananthera and F. assyriaca mainly by its smooth style, longer filaments and more numerous bracts, and from F. caucasica and F. baskilensis mainly by its striped perigone and more numerous bracts. Diagnostic characteristics, a description, images, and a conservation assessment are provided.
Mehmet Maruf Balos and Musa Geçit
Finnish Zoological and Botanical Publishing Board
Allium farashinense Balos & Geçit (Amaryllidaceae) is described as a new species from Şırnak Province, eastern Turkey. Diagnostic characteristics, a comprehensive description, images of the species, and a distribution map are provided. Based on morphology, it belongs to Allium subgen. Polyprason sect. Scorodon. It resembles A. anacoleum, A. capitellatum, A. longivaginatum and A. microspathum, but morphologically differs from them by e.g. bulb size, stem length, leaf sheath, leaf shape, perigon colour, outer and inner tepals, and different filaments.
Mehmet Maruf Balos and Musa Geçit
Finnish Zoological and Botanical Publishing Board
Allium calyanense Balos & Geçit (Amaryllidaceae) is described as a new species from Van Province, eastern Anatolia, Turkey. Diagnostic characteristics, a comprehensive description, photographs of the species and a distribution map are provided. Based on morphology, it belongs to Allium subgen. Polyprason sect. Scorodon. It resembles A. anacoleum, A. capitellatum and A. microspathum but morphologically differs from them by e.g. bulb size, stem length, leaf sheath, leaf shape, perigon colour, size and colour of outer and inner tepals, and different filaments.
Alessandra Acquaviva, Simonetta Cristina Di Simone, Nilofar, Abdelhakim Bouyahya, Gokhan Zengin, Lucia Recinella, Sheila Leone, Luigi Brunetti, Abdullahi Ibrahim Uba, Osman Guler,et al.
MDPI AG
Plants from the Nepeta genus have been proved to possess different pharmacological properties, among which are antimicrobial, antioxidant, anti-inflammatory, analgesic, and cytotoxic effects. Nepeta italica is a medicinal plant traditionally used for its analgesic effects, and in the present study, the phytochemical composition and biological effects of hexane, dichloromethane (DCM), ethyl acetate (EA), ethanol, ethanol-water, and water extracts of the aerial parts were investigated for determining phenolic composition, antioxidant effects, and anti-inflammatory effects in isolated mouse colon specimens exposed to lipopolysaccharide (LPS). Polar extracts were the richest in terms of phenolic compounds, especially rosmarinic acid. In parallel, ethanol, ethanol-water, and water extracts were also the most effective as scavenging/reducing and enzyme inhibition agents, especially towards cholinesterases and α-glucosidase, and in inhibiting the LPS-induced cyclooxygenase-2 (COX-2) and tumor necrosis factor α (TNFα) gene expression in mouse colon. This poses the basis for future in vivo investigations for confirming the protective effects of polar extracts of N. italica against inflammatory bowel diseases.
Veysel Sonay, Mehtap Tekşen, Hasan Yıldırım, Mehmet Maruf Balos, and Hasan Akan
Wiley
Veysel Agan, Ismail Koyuncu, Fatma Zehra Agan, and Mehmet Maruf Balos
MDPI AG
This study investigated the antioxidant and anticancer properties, phenolic compounds, and content profile of Hypericum salsolifolium plant extracts prepared with different solvents. The total phenolic content, total flavonoid content, and antioxidant potential [(2,2-diphenyl-1-picrylhydrazyl, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), ferric reducing antioxidant power, and cupric reducing antioxidant capacity assays] of Hypericum salsolifolium extracts obtained using solvents of different polarities (hexane, dichloromethane, methanol, and water) were measured using spectrophotometric methods. The contents of the extracts were analyzed using liquid chromatography–mass spectrometry and inductively coupled plasma—mass spectrometry methods. Anticancer detection was performed in human lung carcinoma cells using the 3-4,5-dimethylthiazol-2,5-diphenyltetrazolium bromide, annexin-V, and cell cycle assays, as well as fluorescence detection of acridine orange/ethidium bromide staining. The methanolic extract was determined to have higher activation values of total phenolics, total flavonoids, ferric reducing antioxidant power, and in the 2,2-diphenyl-1-picrylhydrazyl assay than the other extracts, and the aqueous extract had higher values in the 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and cupric reducing antioxidant capacity assays. The methanolic extract showed a cytotoxic effect against human lung carcinoma cells (IC50: 141.96 µg/mL). It was found that Hypericum salsolifolium extract showed antioxidant and anticancer activities. It was concluded that this plant can be used as a nutritional supplement due to its glucose, phenolic compound, amino acid, and vitamin content.
Ebru Yuce Babacan, Dimitrina Zheleva-Dimitrova, Reneta Gevrenova, Abdelhakim Bouyahya, Mehmet Maruf Balos, Ugur Cakilcioglu, Kouadio Ibrahime Sinan, and Gokhan Zengin
MDPI AG
The study aimed at the metabolite profiling and evaluation of antioxidant and enzyme inhibitory properties of methanol extracts from flowers, leaves, and tubers of unexplored Eminium intortum (Banks & Sol.) Kuntze and E. spiculatum (Blume) Schott (Araceae). A total of 83 metabolites, including 19 phenolic acids, 46 flavonoids, 11 amino, and 7 fatty acids were identified by UHPLC-HRMS in the studied extracts for the first time. E. intortum flower and leaf extracts had the highest total phenolic and flavonoid contents (50.82 ± 0.71 mg GAE/g and 65.08 ± 0.38 RE/g, respectively). Significant radical scavenging activity (32.20 ± 1.26 and 54.34 ± 0.53 mg TE/g for DPPH and ABTS) and reducing power (88.27 ± 1.49 and 33.13 ± 0.68 mg TE/g for CUPRAC and FRAP) were observed in leaf extracts. E. intortum flowers showed the maximum anticholinesterase activity (2.72 ± 0.03 mg GALAE/g). E. spiculatum leaves and tubers exhibited the highest inhibition towards α-glucosidase (0.99 ± 0.02 ACAE/g) and tirosinase (50.73 ± 2.29 mg KAE/g), respectively. A multivariate analysis revealed that O-hydroxycinnamoylglycosyl-C-flavonoid glycosides mostly accounted for the discrimination of both species. Thus, E. intortum and E. spiculatum can be considered as potential candidates for designing functional ingredients in the pharmaceutical and nutraceutical industries.
MUSTAFA KESKİN, VEYSEL SONAY, and MEHMET MARUF BALOS
Magnolia Press
Trifolium elazizense, a new species of Trifolium sect. Trifolium from East Anatolia in Turkey is described. It grows in subalpine regions with steep slopes and shallow soil at high altitudes. The new species is morphologically close to T. longidentatum and T. kurdistanicum, and can be considered a member of the new subsect. Stipulia. Trifolium elazizense is characterized by hairy stipules, the throat of calyx closed by callus hairs, inflorescences without bracts, obviously unequal calyx teeth, longest tooth 3-nerved, others 1–3 nerved.
MEHMET MARUF BALOS, VEYSEL SONAY, CAHİT ÇEÇEN, and HASAN AKAN
Magnolia Press
Allium murat-sonayii Balos, Sonay & C. Çeçen is described as a new species from Elazığ Province, Eastern Türkiye. Diagnostic characteristics, a comprehensive description, photographs and a distribution map are provided. Based on morphological features, it belongs in Allium subgen. Allium sect. Allium. It is similar to A. stearnianum, A. stearnianum subsp. vanense, A. aybukeae, A. gemiciana, A. yamadagensis and A. dictyoprasum, but differs from them by several morphological characters, such as bulblets color, stem length, leaf, umbel shape, perigon colour, outer and inner tepal, anther colour, filaments and ovary.
Cahit Çeçen, Hasan Akan, Hasan Yıldırım, and Mehmet Maruf Balos
Finnish Zoological and Botanical Publishing Board
Mehmet Maruf BALOS
Commagene Journal of Biology
In this article, Cleome quinquenervia (Cleomaceae) species is reported as a new record for the flora of Turkey based on the samples collected from Şanlıurfa, Mardin, and Adıyaman provinces. A detailed description and particular photographs of this species are given based on the large number of specimens collected. The meticulous comparison of the descriptions of the C. quinquenervia species and the information obtained in this study were made by examining the floras of the nearby countries. In addition, the systematical, ethnobotanical, and pharmacological features of the genus Cleome are summarized.
Mehmet Maruf Balos, Hasan Akan, Hasan Yıldırım, and Musa Geçit
Finnish Zoological and Botanical Publishing Board
Allium mardinense Balos, H. Akan & Yıldırım, a new species of Allium sect. Allium, is described from Mardin Province, southeastern Turkey. It resembles A. aybukeae and A. enginii but differs from them by several morphological characters, such as its filament length, inner tepal shape and surface, and anther colour. Diagnostic characters, a comprehensive description, photographs, and a distribution map of A. mardinense are provided.
Fatih Satıl, Hasan Akan, Mehmet Karaaslan, Mehmet Maruf Balos, and Bülent Başyiğit
Polish Botanical Society
Abstract Oak molasses, called “Gezo,” have been produced by the local people of Southeastern Anatolia. In this study, the ethnobotanical characteristics, production stages, health effects, and chemical composition of Gezo were determined. Traditional Gezo molasses is produced from the acorn of Quercus brantii Lindl. The survey was carried out in seven provinces with large populations. Molasses samples were collected from local producers in the region alongside the local names, usage, sorting, and grading methods used by the local people. The total contents of phenolics and flavanoids were found to vary between the range of 1.60–2.56 mg gallic acid equivalents (GAE) and 0.62–0.72 mg rutin (RE) per g of Gezo molasses, respectively. Gezo displayed scavenging activity against DPPH radicals ranging from 7.57 to 9.44 µM Trolox/g. The CUPRAC assay results showed that molasses also possessed reducing power activity with a value of 8.57–10.20 µM Trolox/g. Gezo is typically consumed by local people as a breakfast food. However, it is also used for medical purposes to treat bronchitis, cough, asthma, and diabetes. The region’s oak species are used by locals for fuel, feed, handicrafts, and games.