Aida Abdybekova
Verified @gmail.com
Professor of veterinary medicine Kazakh scientific-research of veterinary institute
Scopus Publications
Scopus Publications
Erzhan Zh Kidiraliyev, Ainur A. Zhaksylykova, Eleonora A. Kydyrkhanova, Kaissar Zh Kushaliyev, Alexandr Shevtsov, Ryskeldina Anara, Zhibek P. Sembaeva, M.A. Arzybaev, Christine M. Budke, and Aida M. Abdybekova
Elsevier BV
Rabiga Uakhit, Sofiya Yalysheva, Aida Abdybekova, Ainura Smagulova, Lyudmila Lider, Karina Jazina, Aidana Tautanova, and Vladimir Kiyan
Veterinary World
Background and Aim: In Kazakhstan, the study of Echinococcus infection among farm animals is crucial to monitor the invasion among livestock and map the data obtained. Unfortunately, there are only partial data on the study of Echinococcus among cattle’s in Kazakhstan, which makes it difficult to conduct a comparative analysis of the epidemiological situation among livestock animals. The present study aimed to molecularly identify the species and haplotypes of the E. granulosus complex infecting cattle in Kazakhstan and investigate their genetic variation relative to mitochondrial (mt) targets. Materials and Methods: Individual cyst isolates (n = 700) were collected from infected cattle lungs and livers after slaughter from the slaughterhouse. Total DNA was extracted from the germinal layers of the cyst from each isolate. This DNA sequenced partial mt genes of cytochrome c oxidase 1 (450 bp) and NADH dehydrogenase 1 (1200 bp). Results: We determined that all the sequences were detected as E. granulosus s.s., of which 69 (94.5%) samples belonged to G1, and only 4 (5.4%) samples belonged to the G3 genotype. After bioinformatic analysis, 38 haplotypes were identified. Conclusion: Our findings revealed that the G1 genotype of E. granulosus s.s. is the predominant cattle genotype in Kazakhstan. However, only one region showed the presence of two genotypes G1 and G3, in the sequence, which suggests that further research is needed to investigate the epidemiology of Echinococcus infection in cattle in Kazakhstan. Keywords: cattle, cystic echinococcosis, Echinococcus granulosus, genotypes, haplotype, Kazakhstan.
Jan Miciński, Gulzat Tolepova, Aida Abdybekova, Akylbek Zhumageldiyev, Jan Miciński, Altay Ussenbayev, Mirosława Witkowska-Dąbrowska, and Wiesław Sobotka
Polish Society for Magnesium Research
Aida M. Abdybekova, Ainur A. Zhaksylykova, Kaissar Zh Kushaliyev, Erzhan Zh Kidiraliyev, Aigerim R. Kozhayeva, Ulbolsyn Zh Kuzhebayeva, Alexey Grachev, Alexandr Shevtsov, and Christine M. Budke
Elsevier BV
Marat Zhaksylykovich Aubakirov, Aida Makenovna Abdybekova, Madina Asylkhanovna Khassanova, Azamat Zhaksibekovich Issabayev, Nurlan Sarsenbayevich Kaumenov, Alexandra Alekseevna Tegza, Vladislav Andreevic Sapa, Vladimir Nikolaevich Domatsky, Evgenia Nikolaevna Erenko, and Karina Namazbaevna Namazbai
Science Publications
: The aim was to study the epizootological situation, as well as the characteristics of the territories of Kostanay and North Kazakhstan regions on fish opisthorchiasis. The object of the study is the reservoirs of Kostanay and the North Kazakhstan region (rivers Torgai, Tobol, and Ishim). To date, there is a need to develop monitoring methods to assess the epidemiological and epizootological significance of various environmental objects in the transmission of invasive material and the spread of invasions. These studies will contribute to the rationalization of veterinary and sanitary supervision. The conducted studies have allowed us to define the leading factors of the spread of opisthorchiasis in Kazakhstan. A diagnostic algorithm has been developed to improve its efficiency. The results can be used in the organizational and methodological aspects when conducting epidemiological surveillance of opisthorchiasis. The area of the pathogen of opisthorchiasis Opisthorchis felineus covers the territories of Pavlodar, Akmola, Karaganda, Aktobe, and West Kazakhstan regions, extending from the eastern to western borders of Kazakhstan. This disease, according to the Republican Epidemiological Station, has recently been trending upward among the population, which indicates an alarming epidemiological situation in Kazakhstan. As a result of epidemiological monitoring of the incidence of opisthorchiasis in the Kostanay and North Kazakhstan regions, it was found that over the past 10 years (2011-2021), 549 and 29 cases of opisthorchiasis had been registered, respectively. In the Kostanay region, the largest number of cases occurred in 2011 and 2012 (76 and 77 cases, respectively).
A.M. Abdybekova, S.Zh. Assylbekova, A.A. Abdibayeva, A.A. Zhaksylykova, B.I. Barbol, M.Zh. Aubakirov, and P.R. Torgerson
Cambridge University Press (CUP)
Abstract The northern section of the Caspian Sea and lower reaches of the Zhaiyk (Ural) River is an important fishery for Kazakhstan. In the present study, a total of 1597 individuals of ten fish species were analysed. The fish were caught over three years, from 2018 to 2020. For each species studied – Abramis brama, Alosa saposchnikowii, Atherina boyeri caspia, Carassius gibelio, Chelon auratus, Cyprinus carpio, Leuciscus aspius, Rutilus caspius, Sander marinus and Sander volgensis – between 100 and 200 individuals were examined. A series of generalized linear models (GLMs) were used to examine the association between individual parasite intensity of infection and the Fulton index, age, year the fish was captured, where the fish was captured (northern Caspian or Zhaiyk River) and sex. For each GLM, the best-fitting probability distribution was used –either Poisson, zero-inflated Poisson, negative binomial or zero-inflated negative binomial. For some fish/parasite species, an increased Fulton index was associated with higher intensities of parasite infection, whilst, for others, the Fulton index decreased with the intensity of parasite infection. This was also true of age-related intensity of infection, with some parasites having an increased intensity of infection with age whilst others had a decreased intensity of infection with age. There was also some evidence of variation in intensity of parasite infection between different years when the fish were caught. For some species of fish that are endemic to both the fresh waters of the Zhaiyk River and the low-saline waters of the northern Caspian, there were variations in intensity of parasite infection between the two environments. The best-fitting probability distribution also gave some information about the dynamics of infection. No fish species had a Poisson distribution of parasites, which is consistent with an entirely random infection process, with all fish being potentially exposed. For some parasites, the distribution was a zero-inflated Poisson, which is consistent with either the fish being exposed to parasite infection or not; and, if exposed, infection was a random process. Other parasites had a negative binomial distribution, consistent with the entire fish population being exposed, but the infection process was clumped or there were variations in the susceptibility of infection between fish. Finally, some of the parasites had a zero-inflated negative binomial distribution, which can be interpreted as part of the fish population not being exposed and the remainder of the population being exposed to a clumped or aggregated infection process and/or a variation in individual susceptibility to infection.
A. M. Abdybekova, A. A. Abdibayeva, N. N. Popov, A. A. Zhaksylykova, B. I. Barbol, B. Zh. Bozhbanov, and P. R. Torgerson
Walter de Gruyter GmbH
Summary The northern section of the Caspian Sea is an important fishery for Kazakhstan. In the present study, a total of 606 individuals of 13 fish species were collected. For each of Abramis brama, Alosa saposchnikowii, Atherina boyeri caspia, Carassius auratus, Clupeonella cultriventris, Cyprinus carpio, Liza aurata, Leuciscus aspius, Rutilus rutilus caspius, Sander lucioperca, Sander marinus, and Sander volgensis 50 individuals were examined whilst 6 individuals of Siluris glanis were examined. The nematode parasite Anisakis schupakovi was found in all fish species except Liza aurata, Carassius aurata, Cyprinus carpio and Rutilus rutilus at intensities ranging from 1 to 1197 parasites per infected fish. Trematodes of family Diplostomidae were also isolated from all fish except Alosa saposhnikowii, Clupeonella cultriventris and Sander marinus at intensities ranging from 1 to 242 parasites per infected fish. Other parasites found included the nematodes Porrocaecum reticulatum, Contracecum sp, Camallanus sp and Eustrongylus excisus; the cestodes Neogryporhynchus cheilancristrotus, Bothriocephalus opsariichthydis; the monogenean parasites Mazocraes alosa, Ancyrocephalus paradocus, Gyrodactylus spp, Ligophorus vanbenedenii and Dactylogyrus spp; and the crustacean parasites Ergasilus sp. and Synergasilus sp. In addition one unidentified species of nematode and a bivalve of the genus Unio was recovered from Rutilus rutilus caspius. There was no association between Fulton’s condition index and intensity of parasite infection.
A.M. Abdybekova, Z. Zhang, A.A. Sultanov, A.A. Abdibayeva, A.A. Zhaksylykova, S.M. Junisbayeva, M.Zh. Aubakirov, G.D. Akhmetova, and P.R. Torgerson
Cambridge University Press (CUP)
Abstract The diversity and importance of Echinococcus species in domesticated animals in Kazakhstan are poorly understood. In this study, 17 cysts of Echinococcus were collected from cattle and a further 17 cysts from sheep. DNA was extracted from the individual cysts and used for polymerase chain reaction amplification of mitochondrial subunit 1 of the cox1 and nadh1 gene. Amplicon sequencing results revealed the presence of Echinococcus granulosus sensu stricto G1 in 15 cattle and 15 sheep, and G3 genotype from two cattle. Echinococcus canadensis (G6/G7 strain) was found in two cysts originating from sheep.
Paul R. Torgerson, Aida M. Abdybekova, Gulnara Minbaeva, Zhanna Shapiyeva, Lian F. Thomas, Veronique Dermauw, Brecht Devleesschauwer, Sarah Gabriël, Pierre Dorny, Uffe Christian Braae,et al.
Springer Science and Business Media LLC
Aida M. Abdybekova, Akhmetzhan A. Sultanov, Nurgul M. Dzhusupbekova, Aigerim A. Abdibayeva, Ainur A. Zhaksylykova, Raushan A. Kerimbaeva, Gulnazi D. Akhmetova, and Paul R. Torgerson
Elsevier BV
Akmetzhan A. Sultanov, Sarsenbay K. Abdrakhmanov, Aida M. Abdybekova, Bolat S. Karatayev, and Paul R. Torgerson
Public Library of Science (PLoS)
Background Rabies is a neglected zoonotic disease. There is a sparsity of data on this disease with regard to the incidence of human and animal disease in many low and middle income countries. Furthermore, rabies results in a large economic impact and a high human burden of disease. Kazakhstan is a large landlocked middle income country that gained independence from the Soviet Union in 1991 and is endemic for rabies. Methodology/Principal Findings We used detailed public health and veterinary surveillance data from 2003 to 2015 to map where livestock rabies is occurring. We also estimate the economic impact and human burden of rabies. Livestock and canine rabies occurred over most of Kazakhstan, but there were regional variations in disease distribution. There were a mean of 7.1 officially recorded human fatalities due to rabies per year resulting in approximately 457 Disability Adjusted Life Years (DALYs). A mean of 64,289 individuals per annum underwent post exposure prophylaxis (PEP) which may have resulted in an additional 1140 DALYs annually. PEP is preventing at least 118 cases of human rabies each year or possibly as many as 1184 at an estimated cost of $1193 or $119 per DALY averted respectively. The estimated economic impact of rabies in Kazakhstan is $20.9 million per annum, with nearly half of this cost being attributed to the cost of PEP and the loss of income whilst being treated. A further $5.4 million per annum was estimated to be the life time loss of income for fatal cases. Animal vaccination programmes and animal control programmes also contributed substantially to the economic losses. The direct costs due to rabies fatalities of agricultural animals was relatively low. Conclusions/Significance This study demonstrates that in Kazakhstan there is a substantial economic cost and health impact of rabies. These costs could be reduced by modifying the vaccination programme that is now practised. The study also fills some data gaps on the epidemiology and economic effects of rabies in respect to Kazakhstan.
A. Abdybekova, A. Sultanov, B. Karatayev, A. Zhumabayeva, Z. Shapiyeva, T. Yeshmuratov, D. Toksanbayev, R. Shalkeev, and P.R. Torgerson
Cambridge University Press (CUP)
AbstractKazakhstan is highly endemic for echinococcosis. Both Echinococcus granulosus and E. multilocularis are widely distributed in the country. Official records of human cystic echinococcosis over the past 5–10 years suggest a stable incidence of approximately 800–1000 cases per year, which is 5 cases per 100,000 per year. This followed a rapid increase in the incidence following the dissolution of the Soviet Union. Between 2007 and 2013, 5949 cases were reported in the national surveillance data. The prevalence in sheep, based on slaughterhouse studies, suggests that between 30 and 50% of sheep are infected with hydatid cysts, while cattle have a prevalence of approximately 7%. Rural dogs have a high prevalence of infection of between 5 and 10%, with shepherd dogs having prevalences of over 20%. G1 and G6/7 strains of E. granulosus have been isolated from dogs in Kazakhstan. Wolves are also infected, with one prevalence estimate of approximately 20%. The incidence of human alveolar echinococcosis is less clear, although estimates from Kazakhstani expatriates living in Germany and the hospital records of a single referral centre in Almaty suggest 34 or 130 cases per year (or an annual incidence of 0.20 or 0.76 cases per 100,000), respectively, could be occurring in Kazakhstan. Studies suggest that in some rural dog populations the prevalence may be about 5%. The parasite is widely distributed in foxes and small mammals through much of Kazakhstan.
A. Sultanov, A. Abdybekova, A. Abdibaeva, Z. Shapiyeva, T. Yeshmuratov, and P.R. Torgerson
Elsevier BV
A.M. Abdybekova and P.R. Torgerson
Elsevier BV
P.R. Torgerson, K.K. Burtisurnov, B.S. Shaikenov, A.T. Rysmukhambetova, A.M. Abdybekova, and A.E. Ussenbayev
Elsevier BV
P. R. TORGERSON, B. S. SHAIKENOV, A. T. RYSMUKHAMBETOVA, A. E. USSENBAYEV, A. M. ABDYBEKOVA, and K. K. BURTISURNOV
Cambridge University Press (CUP)
Cystic echinococcosis, caused by Echinococcus granulosus, is an emerging disease in many parts of the world and, in particular, in eastern Europe and the former Soviet Union. This paper examines the abundance of infection of E. granulosus in the definitive host in southern Kazakhstan. Observed data are fitted to a mathematical model in order to decide if the parasite population is partly regulated by definitive host immunity and to define parameters in the model. Such data would be useful to develop simulation models for the control of this disease. Maximum likelihood techniques were used to define the parameters and their confidence limits in the model and the negative binomial distribution was used to define the error variance in the observed data. The results indicated that there were 2 distinct populations of dogs in rural Kazakhstan which had significantly different exposures to E. granulosus. Farm dogs, which are closely associated with livestock husbandry, particularly sheep rearing, had a relatively high mean abundance of 631 parasites per dog and a prevalence rate of approximately 23%. The best fit to the model indicated that there was significant herd immunity in the dog at this infection pressure. In contrast, village dogs which were more likely to be kept as pets had a much lower mean abundance of parasites of only 27 parasites per dog and a lower prevalence of 5·8%. With this village population of dogs, the best fit indicated negligible herd immunity.
B.S Shaikenov, P.R Torgerson, A.E Usenbayev, K.K Baitursynov, A.T Rysmukhambetova, A.M Abdybekova, and K.O Karamendin
Elsevier BV
P.R. Torgerson, B.S. Shaikenov, K.K. Baitursinov, and A.M. Abdybekova
Oxford University Press (OUP)