Isaeva Iuliia

@ispm.ru

Enikolopov Institute of Synthetic Polymeric Materials



           

https://researchid.co/isaevaya

RESEARCH, TEACHING, or OTHER INTERESTS

Chemistry, Biochemistry, Organic Chemistry

4

Scopus Publications

Scopus Publications

  • Green Light Activated Dual-Action Pt(IV) Prodrug with Enhanced PDT Activity
    Daniil Spector, Vladislav Bykusov, Yulia Isaeva, Roman Akasov, Anastasia Zharova, Igor Rodin, Mikhail Vokuev, Yuri Grishin, Vita Nikitina, Alexander Martynov,et al.
    Wiley
    AbstractLight induced release of cisplatin from Pt(IV) prodrugs is a promising tool for precise spatiotemporal control over the antiproliferative activity of Pt‐based chemotherapeutic drugs. A combination of light‐controlled chemotherapy (PACT) and photodynamic therapy (PDT) in one molecule has the potential to overcome crucial drawbacks of both Pt‐based chemotherapy and PDT via a synergetic effect. Herein we report green‐light‐activated Pt(IV) prodrug GreenPt with BODIPY‐based photosentitizer in the axial position with an incredible high light response and singlet oxygen generation ability. GreenPt demonstrated the ability to release cisplatin under low‐dose green light irradiation up to 1 J/cm2. The investigation of the photoreduction mechanism of GreenPt prodrug using DFT modeling and ΔG0 PET estimation revealed that the anion‐radical formation and substituent photoinduced electron transfer from the triplet excited state of the BODIPY axial ligand to the Pt(IV) center is the key step in the light‐induced release of cisplatin. Green‐light‐activated BODIPY‐based photosentitizers 5 and 8 demonstrated outstanding photosensitizing properties with an extraordinary phototoxicity index (PI)>1300. GreenPt prodrug demonstrated gradual intracellular accumulation and light‐induced phototoxicity with PI>100, thus demonstrating dual action through light‐controlled release of both cisplatin and a potent BODIPY‐based photosensitizer.

  • Nanoformulation of the Photoactive Cisplatin Prodrug for Combined Photothermal Therapy and Bioimaging
    Daniil V. Spector, Vladislav Bykusov, Anastasia Zharova, Ilia Kuzmichev, Yulia A. Isaeva, Evgeny V. Khaydukov, Ekaterina Trifanova, Maxim Stepanov, Alexander S. Erofeev, Petr Gorelkin,et al.
    American Chemical Society (ACS)

  • Nanoparticles of Push-Pull Triphenylamine-Based Molecules for Light-Controlled Stimulation of Neuronal Activity
    Yuriy N. Luponosov, Alexander N. Solodukhin, Nikolay A. Aseyev, Tatyana I. Rokitskaya, Darya E. Kolotova, Elena A. Kotova, Tikhon S. Kurkin, Liya A. Poletavkina, Yulia A. Isaeva, Yuri N. Antonenko,et al.
    American Chemical Society (ACS)
    Organic semiconductor materials with a unique set of properties are very attractive for interfacing biological objects and can be used for noninvasive therapy or detection of biological signals. Here, we describe the synthesis and investigation of a novel series of organic push-pull conjugated molecules with the star-shaped architecture, consisting of triphenylamine as a branching electron donor core linked through the thiophene π-spacer to electron-withdrawing alkyl-dicyanovinyl groups. The molecules could form stable aqueous dispersions of nanoparticles (NPs) without the addition of any surfactants or amphiphilic polymer matrixes with the average size distribution varying from 40 to 120 nm and absorption spectra very similar to those of human eye retina pigments such as rods and green cones. Variation of the terminal alkyl chain length of the molecules forming NPs from 1 to 12 carbon atoms was found to be an efficient tool to modulate their lipophilic and biological properties. Possibilities of using the NPs as light nanoactuators in biological systems or as artificial pigments for therapy of degenerative retinal diseases were studied both on the model planar bilayer lipid membranes and on the rat cortical neurons. In the planar bilayer system, the photodynamic activity of these NPs led to photoinactivation of ion channels formed by pentadecapeptide gramicidin A. Treatment of rat cortical neurons with the NPs caused depolarization of cell membranes upon light irradiation, which could also be due to the photodynamic activity of the NPs. The results of the work gave more insight into the mechanisms of light-controlled stimulation of neuronal activity and for the first time showed that fine-tuning of the lipophilic affinity of NPs based on organic conjugated molecules is of high importance for creating a bioelectronic interface for biomedical applications.

  • Synthesis, structure, and PDE inhibiting activity of the anionic DNIC with 5-(3-pyridyl)-4H-1,2,4-triazole-3-thiolyl, the nitric oxide donor
    Natalia A. Sanina, Yuliya A. Isaeva, Andrey N. Utenyshev, Pavel V. Dorovatovskii, Nickolai S. Ovanesyan, Nina S. Emel'yanova, Olesya V. Pokidova, Liliya V. Tat'yanenko, Il'ya V. Sulimenkov, Alexandr I. Kotel'nikov,et al.
    Elsevier BV