Cintia Figueiredo de Araujo

PhD in Sciences from Immunology from the Federal University of Bahia (2018), Master of Science from the Postgraduate in Biotechnology in Health and Investigative Medicine from the Gonçalo Moniz da Bahia Research Center (2013) and graduated in Veterinary Medicine from the Federal University (2010). Professor in the Centro Universitário UNFG (2018 - 2020) and Federal University of West Bahia (UFOB) (2021) and the Post-Doctoral degree at the Gonçalo Moniz Research Instinct - FIOCRUZ (Bahia).

RESEARCH, TEACHING, or OTHER INTERESTS

General Veterinary, Immunology, Parasitology

Scopus Publications

Follow up of a robust meta-signature to identify zika virus infection in aedes aegypti: Another brick in the wall
Eduardo Fukutani, Moreno Rodrigues, José Irahe Kasprzykowski, Cintia Figueiredo de Araujo, Alexandre Rossi Paschoal, Pablo Ivan Pereira Ramos, Kiyoshi Ferreira Fukutani, and Artur Trancoso Lopo de Queiroz
FapUNIFESP (SciELO)
The mosquito Aedes aegypti is the main vector of several arthropod-borne diseases that have global impacts. In a previous meta-analysis, our group identified a vector gene set containing 110 genes strongly associated with infections of dengue, West Nile and yellow fever viruses. Of these 110 genes, four genes allowed a highly accurate classification of infected status. More recently, a new study of Ae. aegypti infected with Zika virus (ZIKV) was published, providing new data to investigate whether this “infection” gene set is also altered during a ZIKV infection. Our hypothesis is that the infection-associated signature may also serve as a proxy to classify the ZIKV infection in the vector. Raw data associated with the NCBI/BioProject were downloaded and re-analysed. A total of 18 paired-end replicates corresponding to three ZIKV-infected samples and three controls were included in this study. The nMDS technique with a logistic regression was used to obtain the probabilities of belonging to a given class. Thus, to compare both gene sets, we used the area under the curve and performed a comparison using the bootstrap method. Our meta-signature was able to separate the infected mosquitoes from the controls with good predictive power to classify the Zika-infected mosquitoes.


Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice
Viviane Costa Junqueira Rocha, Luciana Souza de Aragão França, Cintia Figueiredo de Araújo, Ayling Martins Ng, Candace Machado de Andrade, André Cronemberger Andrade, Emanuelle de Souza Santos, Mariana da Cruz Borges-Silva, Simone Garcia Macambira, Alberto Augusto Noronha-Dutra,et al.
Springer Science and Business Media LLC



Enhancement of experimental cutaneous leishmaniasis by Leishmania extract: Identification of a disease-associated antibody specificity Immunology
Virgínia M. G. Silva, Cíntia F. de-Araújo, Isabela C. Navarro, Pablo R. S. Oliveira, and Lain Pontes–de-Carvalho
Springer Science and Business Media LLC



Extracellular Vesicles from Leishmania-Infected Macrophages Confer an Anti-infection Cytokine-Production Profile to Naïve Macrophages
André Cronemberger-Andrade, Luciana Aragão-França, Cintia Figueiredo de Araujo, Viviane Junqueira Rocha, Mariana da Cruz Borges-Silva, Cláudio P. Figueiras, Pablo R. Oliveira, Luiz A. R. de Freitas, Patrícia S. T. Veras, and Lain Pontes-de-Carvalho
Public Library of Science (PLoS)
Background Extracellular vesicles (EVs) are structures with phospholipid bilayer membranes and 100–1000 nm diameters. These vesicles are released from cells upon activation of surface receptors and/or apoptosis. The production of EVs by dendritic cells, mast cells, macrophages, and B and T lymphocytes has been extensively reported in the literature. EVs may express MHC class II and other membrane surface molecules and carry antigens. The aim of this study was to investigate the role of EVs from Leishmania-infected macrophages as immune modulatory particles. Methodology/Principal Findings In this work it was shown that BALB/c mouse bone marrow-derived macrophages, either infected in vitro with Leishmania amazonensis or left uninfected, release comparable amounts of 50–300 nm-diameter extracellular vesicles (EVs). The EVs were characterized by flow cytometry and electron microscopy. The incubation of naïve macrophages with these EVs for 48 hours led to a statistically significant increase in the production of the cytokines IL-12, IL-1β, and TNF-α. Conclusions/Significance EVs derived from macrophages infected with L. amazonensis induce other macrophages, which in vivo could be bystander cells, to produce the proinflammatory cytokines IL-12, IL-1β and TNF-α. This could contribute both to modulate the immune system in favor of a Th1 immune response and to the elimination of the Leishmania, leading, therefore, to the control the infection.


Leishmania braziliensis and Leishmania amazonensis amastigote extracts differ in their enhancement effect on Leishmania infection when injected intradermally
Cintia F de Araújo, Virgínia MG Silva, Andre Cronemberger-Andrade, Luciana S Aragão-França, Viviane CJ Rocha, Priscila SL Santos, and Lain Pontes-de-Carvalho
Springer Science and Business Media LLC